Winona Sensitive Skin Moisturizing Tolerance-Extreme Cream, second generation, developed for sensitive skin. Product slogans: helps care for sudden sensitivity; use daily to help reduce recurrence; for dry, red, hot-feeling skin in summer, use the cream.

Sun exposure and seasonal changes may aggravate sudden skin sensitivity, with dryness, redness, tightness, and heat.

The source states that, according to statistics, 1 in every 3 people nationwide experiences sensitivity caused by sunlight.

Image labels: dryness, redness, irritation, and redness with heat. Brand: Winona.

Helps repair sudden dryness, redness, and heat, and promotes healthier, more resilient-looking skin.

Rapid redness reduction: -73%; redness reduction in 15 minutes.

Strong soothing: -76%; skin heat sensation in 15 minutes.

Deep repair: +28%; dermal density.

Product benefits: Quickly soothes sudden sensitivity and helps reduce recurrence over 28 days. The comparisons show reduced skin redness and reduced skin burning sensation after 15 minutes of use. For longer-lasting reduction in recurring sensitivity, the comparison shows increased skin resistance to sun exposure.

The comparison demonstrates increased skin resistance to sun exposure and increased dermal density.

Sensitive Skin Innovation Discovery 2.0. Winona has focused on scientific research for 15 years and found that skin sensitivity is related to a decrease in the sensitivity-related protein CLDN-5. This is Winona Sensitiveness Relieving Series Moisturizing Tolerance-Extreme Cream.

Interrupts the sensitivity transmission pathway to immediately soothe sensitive discomfort. Helps increase the content of key proteins in sensitive skin. Winona’s exclusively researched ingredient: Prinsepia utilis PRO MAX.

Rare Prinsepia utilis fruit is sourced from Haba Snow Mountain in Yunnan. A Prinsepia utilis gene bank is used to select quality fruit from an elevation of approximately 3,000 m.

Only 20 g of Prinsepia utilis PRO MAX is extracted from 1,000 g of Prinsepia utilis kernels. Layered temperature-control extraction technology concentrates 3.8 times the active repairing essence.

WINGNA Sensitiveness Relieving Series.

0 added: no alcohol, fragrance, colorants, or hormones.

Double-skin-milk-like texture that melts on contact with skin, feels fresh, absorbs well, and is not sticky in summer.

15 years of dedicated research on sensitive skin, defining care for sensitive skin.

More than 300 global dermatology studies. Recommended by the World Congress of Dermatology (WCD).

• 8 patents: at the forefront of science and technology
• 3 standards: group standards for the efficacy of soothing skincare products
• 79 authoritative publications (5 SCI papers)
• Validated by 61 authoritative institutions
• Testing on 5,590 people with sensitive skin
• Rigorous testing across 8 dimensions, involving more than 100 person-times

Vacuum-sealed freshness. Twist once, pull twice, replace three times.

Innovative, portable refill; sealed to help prevent leaks and make replacement more reassuring.

Integrated replacement structure for contact-free replacement and freshness.

Suitable for a range of sensitive-skin situations: sudden dryness, itching and redness; tightness, soreness and heat after staying up late; dryness and flaking before makeup; and dryness, redness and heat during travel or seasonal changes.

Winona’s flagship extra-care family: chosen by 40 million people with sensitive skin.

Suitable for all skin types, especially sensitive skin, including skin that becomes sensitive during seasonal changes, experiences redness and discomfort after sun exposure, or is repeatedly sensitive.

The cream can be used daily to help prevent recurring sensitivity. Use it when sensitivity suddenly occurs for immediate soothing. After sensitivity has eased, continued long-term use can help maintain skin stability, improve skin tolerance, and reduce recurring sensitivity.

According to SGS test reports, consumer self-assessment results were recorded after 30 participants used the second-generation cream for 15 minutes. Instrument test results were recorded after 32 Chinese participants with sensitive skin used it for 28 days and then stopped for 7 days. These results are for reference only; actual results vary by person. Consumer self-assessment results were also recorded after 32 Chinese participants with sensitive skin used the cream for 28 days; these results are likewise for reference only, and actual results vary by person.

The Qingciguo fruit used for the second generation is grown at an altitude of about 3,000 meters near Haba Snow Mountain. Winona has included sensitive skin as one of its core research topics since 2011. As of August 2025, dermatology departments at more than 100 Class III Grade A hospitals nationwide had conducted clinical validation of the safety and efficacy of Winona products.

As of August 2025, Winona had 42,468,242 registered members across its online and offline official channels, including Tmall, JD.com, Douyin, Vipshop and counters. The sensitive-skin face cream market research was based on annual sales data for sensitive-skin face creams in mainland China, excluding Hong Kong, Macao and Taiwan, from 2020 to 2024, and was completed in August 2025.

Related research includes “MiRNA-224-5p regulates the defective permeability barrier in sensitive skin by targeting claudin-5” and “Prunsepia utilis Royle polysaccharides promote skin barrier repair through the Claudin family.” The Compendium of Basic Research and Clinical Applications for Sensitive Skin includes 16 national expert guidelines and consensuses, 34 national invention patents, 6 cosmetics-industry group standards, and 286 articles on basic research, process routes and clinical validation.

According to multi-center, large-sample, long-term observational data, the cream was observed at 61 authoritative institutions, covering 5,590 participants. A total of 79 authoritative publications were published, and 8 patents are listed.